6k2c: Difference between revisions
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<StructureSection load='6k2c' size='340' side='right'caption='[[6k2c]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='6k2c' size='340' side='right'caption='[[6k2c]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6k2c]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6k2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K2C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k2c OCA], [https://pdbe.org/6k2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k2c RCSB], [https://www.ebi.ac.uk/pdbsum/6k2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k2c ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/UBE3C_HUMAN UBE3C_HUMAN] E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.<ref>PMID:11278995</ref> <ref>PMID:12692129</ref> <ref>PMID:16341092</ref> <ref>PMID:16601690</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Singh S]] | |||
[[Category: Singh | [[Category: Sivaraman J]] | ||
[[Category: Sivaraman | |||