6k2c: Difference between revisions

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<StructureSection load='6k2c' size='340' side='right'caption='[[6k2c]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6k2c' size='340' side='right'caption='[[6k2c]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6k2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K2C FirstGlance]. <br>
<table><tr><td colspan='2'>[[6k2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K2C FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBE3C, KIAA0010, KIAA10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.26 2.3.2.26] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k2c OCA], [https://pdbe.org/6k2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k2c RCSB], [https://www.ebi.ac.uk/pdbsum/6k2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k2c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k2c OCA], [http://pdbe.org/6k2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k2c RCSB], [http://www.ebi.ac.uk/pdbsum/6k2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k2c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UBE3C_HUMAN UBE3C_HUMAN]] E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.<ref>PMID:11278995</ref> <ref>PMID:12692129</ref> <ref>PMID:16341092</ref> <ref>PMID:16601690</ref>
[https://www.uniprot.org/uniprot/UBE3C_HUMAN UBE3C_HUMAN] E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.<ref>PMID:11278995</ref> <ref>PMID:12692129</ref> <ref>PMID:16341092</ref> <ref>PMID:16601690</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Transferase]]
[[Category: Singh S]]
[[Category: Singh, S]]
[[Category: Sivaraman J]]
[[Category: Sivaraman, J]]
[[Category: E3 ligase]]
[[Category: Hect]]
[[Category: Oncoprotein]]
[[Category: Ubiquitination]]