6kii: Difference between revisions
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==photolyase from Arthrospira platensis== | ==photolyase from Arthrospira platensis== | ||
<StructureSection load='6kii' size='340' side='right'caption='[[6kii]]' scene=''> | <StructureSection load='6kii' size='340' side='right'caption='[[6kii]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KII OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6kii]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KII FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MHF:5,10-METHENYL-6,7,8-TRIHYDROFOLIC+ACID'>MHF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kii OCA], [https://pdbe.org/6kii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kii RCSB], [https://www.ebi.ac.uk/pdbsum/6kii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kii ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to skin cancer. Here, we identified a photolyase from the alga Arthrospira platensis (designated as Ap-phr), which has been regarded as a safe organism for humans for centuries, that can efficiently repair CPD lesions in ssDNA and dsDNA in vitro. The 1.6 A resolution crystal structure of Ap-phr revealed that it possesses a unique methenyltetrahydrofolate chromophore-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications. | |||
A newly identified photolyase from Arthrospira platensis possesses a unique methenyltetrahydrofolate chromophore-binding pattern.,Yan H, Zhu K, Teng M, Li X FEBS Lett. 2020 Feb;594(4):740-750. doi: 10.1002/1873-3468.13657. Epub 2019 Nov, 24. PMID:31675429<ref>PMID:31675429</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6kii" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arthrospira platensis]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Yan H]] | [[Category: Yan H]] | ||
[[Category: Zhu K]] | [[Category: Zhu K]] | ||
