6l8u: Difference between revisions

<table><tr><td colspan='2'>[[6l8u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L8U FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.925&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l8u OCA], [https://pdbe.org/6l8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l8u RCSB], [https://www.ebi.ac.uk/pdbsum/6l8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l8u ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BN3D2_HUMAN BN3D2_HUMAN] O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme (PubMed:28119416). Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs (PubMed:23063121). There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA (PubMed:23063121, PubMed:28119416, PubMed:30127802).<ref>PMID:23063121</ref> <ref>PMID:28119416</ref> <ref>PMID:30127802</ref>  

[[Category: Homo sapiens]]

[[Category: Liu Y]]

[[Category: Martinez A]]

[[Category: Tomita K]]

[[Category: Yamashita S]]