7q8t: Difference between revisions
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==Crystal structure of NAMPT bound to ligand TSY535(compound 9a)== | ==Crystal structure of NAMPT bound to ligand TSY535(compound 9a)== | ||
<StructureSection load='7q8t' size='340' side='right'caption='[[7q8t]]' scene=''> | <StructureSection load='7q8t' size='340' side='right'caption='[[7q8t]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q8T FirstGlance]. <br> | <table><tr><td colspan='2'>[[7q8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q8T FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q8t OCA], [https://pdbe.org/7q8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q8t RCSB], [https://www.ebi.ac.uk/pdbsum/7q8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q8t ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9IY:[(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl+dihydrogen+phosphate'>9IY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q8t OCA], [https://pdbe.org/7q8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q8t RCSB], [https://www.ebi.ac.uk/pdbsum/7q8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q8t ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NAMPT_MOUSE NAMPT_MOUSE] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway.<ref>PMID:12555668</ref> <ref>PMID:15381699</ref> | |||
==See Also== | |||
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Butterworth S]] | [[Category: Butterworth S]] | ||
[[Category: Knapp S]] | [[Category: Knapp S]] | ||
[[Category: Kraemer A]] | [[Category: Kraemer A]] | ||
[[Category: Tang S]] | [[Category: Tang S]] | ||
Latest revision as of 11:04, 22 November 2023
Crystal structure of NAMPT bound to ligand TSY535(compound 9a)
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