2mj0: Difference between revisions

<StructureSection load='2mj0' size='340' side='right'caption='[[2mj0]]' scene=''>

<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [https://pdbe.org/2mj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj0 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/3NO2_NAJKA 3NO2_NAJKA] Neurotoxin that irreversibly inhibits nicotinic acetylcholine receptors (nAChR) and allosterically interacts with muscarinic acetylcholine receptors (mAChR) (PubMed:11279130, PubMed:19682302). The loop II is involved in the interaction of this toxin with nAChR and mAChR (PubMed:27343701, PubMed:26242733). On nAChR, it acts as a competitive antagonist (muscle-type and alpha-7/CHRNA7) with IC(50) values in the micromolar range (PubMed:11279130, PubMed:27343701). On mAChR, in presence of ACh, it partially inhibits the effect of acetylcholine (ACh) (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist) (PubMed:19682302). It also shows a very weak inhibition of GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1 and GABRB3 and GABRG2) subunits (10 uM inhibit 31% current) (PubMed:26221036). In vivo, is nonlethal to mice at concentrations up to 20 mg/kg, but exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats (PubMed:15581687, PubMed:17371532).<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref> <ref>PMID:26221036</ref> <ref>PMID:27343701</ref>

[[Category: Naja kaouthia]]

[[Category: Lyukmanova EN]]

[[Category: Paramonov AS]]

[[Category: Shenkarev ZO]]