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==Crystal structure of the human 4EHP-GIGYF2 complex==
==Crystal structure of the human 4EHP-GIGYF2 complex==
<StructureSection load='5nvl' size='340' side='right' caption='[[5nvl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5nvl' size='340' side='right'caption='[[5nvl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nvl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nvl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NVL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF4E2, EIF4EL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GIGYF2, KIAA0642, PERQ2, TNRC15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvl OCA], [http://pdbe.org/5nvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvl RCSB], [http://www.ebi.ac.uk/pdbsum/5nvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvl OCA], [https://pdbe.org/5nvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nvl RCSB], [https://www.ebi.ac.uk/pdbsum/5nvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/GGYF2_HUMAN GGYF2_HUMAN]] Young adult-onset Parkinsonism. Disease susceptibility may be associated with variations affecting the gene represented in this entry. Its association with Parkinson disease is however unclear. According to a number of studies, variations affecting this gene are not a frequent cause of Parkinson disease, suggesting that GIGYF2 does not play a major role in Parkinson disease etiology (PubMed:19279319, PubMed:19429085, PubMed:19638301, PubMed:19482505, PubMed:20004041, PubMed:19321232, PubMed:20060621).<ref>PMID:19279319</ref> <ref>PMID:19321232</ref> <ref>PMID:19429085</ref> <ref>PMID:19482505</ref> <ref>PMID:19638301</ref> <ref>PMID:20004041</ref> <ref>PMID:20060621</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IF4E2_HUMAN IF4E2_HUMAN]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB:Q8BMB3]<ref>PMID:17368478</ref> <ref>PMID:22751931</ref> <ref>PMID:25624349</ref> <ref>PMID:9582349</ref> [[http://www.uniprot.org/uniprot/GGYF2_HUMAN GGYF2_HUMAN]] Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).[UniProtKB:Q6Y7W8]<ref>PMID:12771153</ref> <ref>PMID:22751931</ref> 
[https://www.uniprot.org/uniprot/IF4E2_HUMAN IF4E2_HUMAN] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB:Q8BMB3]<ref>PMID:17368478</ref> <ref>PMID:22751931</ref> <ref>PMID:25624349</ref> <ref>PMID:9582349</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nvl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nvl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Peter, D]]
[[Category: Large Structures]]
[[Category: Valkov, E]]
[[Category: Peter D]]
[[Category: 4ehp-binding protein]]
[[Category: Valkov E]]
[[Category: Cap-binding protein]]
[[Category: Grb10-interacting gyf protein 2]]
[[Category: Translation]]
[[Category: Translational regulation]]

Latest revision as of 12:10, 22 November 2023

Crystal structure of the human 4EHP-GIGYF2 complex

5nvl, resolution 2.30Å

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