8jt9: Difference between revisions

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~~'''Unreleased structure'''~~

The entry ~~8jt9 is ON HOLD~~

==Human VMAT2 complex with ketanserin==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8jt9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JT9 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8JT9 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UYX:3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione'>UYX</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8jt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jt9 OCA], [https://pdbe.org/8jt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jt9 RCSB], [https://www.ebi.ac.uk/pdbsum/8jt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jt9 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Brain dopamine-serotonin vesicular transport disease. The disease is caused by variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8643547, PubMed:23363473). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238) (By similarity).[UniProtKB:Q01827][UniProtKB:Q8BRU6]<ref>PMID:23363473</ref> <ref>PMID:8643547</ref> <ref>PMID:8860238</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jiang DH]]

[[Category: Wu D]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8jt9 is ON HOLD
+==Human VMAT2 complex with ketanserin==
+<StructureSection load='8jt9' size='340' side='right'caption='[[8jt9]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8jt9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JT9 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UYX:3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione'>UYX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jt9 OCA], [https://pdbe.org/8jt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jt9 RCSB], [https://www.ebi.ac.uk/pdbsum/8jt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jt9 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Brain dopamine-serotonin vesicular transport disease. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8643547, PubMed:23363473). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238) (By similarity).[UniProtKB:Q01827][UniProtKB:Q8BRU6]<ref>PMID:23363473</ref> <ref>PMID:8643547</ref> <ref>PMID:8860238</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jiang DH]]
+[[Category: Wu D]]