6ls5: Difference between revisions

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<StructureSection load='6ls5' size='340' side='right'caption='[[6ls5]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='6ls5' size='340' side='right'caption='[[6ls5]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ls5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LS5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ls5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LS5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EUF:2-(ethyldisulfanyl)-1,3-benzothiazole'>EUF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.031&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FBP1, hCG_1640493 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EUF:2-(ethyldisulfanyl)-1,3-benzothiazole'>EUF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ls5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ls5 OCA], [https://pdbe.org/6ls5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ls5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ls5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ls5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ls5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ls5 OCA], [https://pdbe.org/6ls5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ls5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ls5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ls5 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
== Function ==
[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jian, L]]
[[Category: Jian L]]
[[Category: Jian, W]]
[[Category: Jian W]]
[[Category: Rongrong, S]]
[[Category: Rongrong S]]
[[Category: Shuaishuai, N]]
[[Category: Shuaishuai N]]
[[Category: Yanliang, R]]
[[Category: Yanliang R]]
[[Category: Yixiang, X]]
[[Category: Yixiang X]]
[[Category: Yunyuan, H]]
[[Category: Yunyuan H]]
[[Category: Fbpase]]
[[Category: Hydrolase]]
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