6m2a: Difference between revisions
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<StructureSection load='6m2a' size='340' side='right'caption='[[6m2a]], [[Resolution|resolution]] 2.23Å' scene=''> | <StructureSection load='6m2a' size='340' side='right'caption='[[6m2a]], [[Resolution|resolution]] 2.23Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6m2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[6m2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661] and [https://en.wikipedia.org/wiki/Methanosarcina_barkeri_str._Fusaro Methanosarcina barkeri str. Fusaro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M2A FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m2a OCA], [https://pdbe.org/6m2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m2a RCSB], [https://www.ebi.ac.uk/pdbsum/6m2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m2a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m2a OCA], [https://pdbe.org/6m2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m2a RCSB], [https://www.ebi.ac.uk/pdbsum/6m2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m2a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CFBA_METJA CFBA_METJA] Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.[https://www.uniprot.org/uniprot/CFBA_METBF CFBA_METBF] Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (PubMed:12686546). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:28225763). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (PubMed:28225763).[HAMAP-Rule:MF_00785]<ref>PMID:12686546</ref> <ref>PMID:28225763</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Methanocaldococcus jannaschii DSM 2661]] | ||
[[Category: | [[Category: Methanosarcina barkeri str. Fusaro]] | ||
[[Category: | [[Category: Fujishiro T]] | ||
