7c7b: Difference between revisions

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<StructureSection load='7c7b' size='340' side='right'caption='[[7c7b]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='7c7b' size='340' side='right'caption='[[7c7b]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7c7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7B FirstGlance]. <br>
<table><tr><td colspan='2'>[[7c7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJX:2-azanyl-9-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-6-chloranyl-purin-8-ol'>FJX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRAP1, HSP75 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJX:2-azanyl-9-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-6-chloranyl-purin-8-ol'>FJX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7b OCA], [https://pdbe.org/7c7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7b RCSB], [https://www.ebi.ac.uk/pdbsum/7c7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7b OCA], [https://pdbe.org/7c7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7b RCSB], [https://www.ebi.ac.uk/pdbsum/7c7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN]] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref>
[https://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kang, B H]]
[[Category: Kang BH]]
[[Category: Kang, S]]
[[Category: Kang S]]
[[Category: Kim, D]]
[[Category: Kim D]]
[[Category: Kim, S Y]]
[[Category: Kim SY]]
[[Category: Lee, C]]
[[Category: Lee C]]
[[Category: Park, E]]
[[Category: Park E]]
[[Category: Yang, S]]
[[Category: Yang S]]
[[Category: Yoon, N G]]
[[Category: Yoon NG]]
[[Category: Anticancer]]
[[Category: Chaperone]]
[[Category: Drug]]
[[Category: Hsp90]]
[[Category: Mitochondria]]
[[Category: Selectivity]]
[[Category: Trap1]]
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