7d8d: Difference between revisions
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==== | ==The crystal structure of ScNTM1 in complex with SAH and Rps25a hexapeptide== | ||
<StructureSection load='7d8d' size='340' side='right'caption='[[7d8d]]' scene=''> | <StructureSection load='7d8d' size='340' side='right'caption='[[7d8d]], [[Resolution|resolution]] 1.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7d8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8D FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8d OCA], [https://pdbe.org/7d8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8d RCSB], [https://www.ebi.ac.uk/pdbsum/7d8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8d ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8d OCA], [https://pdbe.org/7d8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8d RCSB], [https://www.ebi.ac.uk/pdbsum/7d8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8d ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NTM1_YEAST NTM1_YEAST] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of the ribosomal proteins RPL12A, RPL12B, RPS25A and RPS25B.<ref>PMID:20481588</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Yue J]] | |||
[[Category: Zhang HY]] | |||
Latest revision as of 16:28, 29 November 2023
The crystal structure of ScNTM1 in complex with SAH and Rps25a hexapeptide
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