7day: Difference between revisions

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<StructureSection load='7day' size='340' side='right'caption='[[7day]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
<StructureSection load='7day' size='340' side='right'caption='[[7day]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7day]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAY FirstGlance]. <br>
<table><tr><td colspan='2'>[[7day]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=H1X:2-[(5-tert-butyl-2-methyl-phenyl)sulfonylamino]benzoic+acid'>H1X</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6kem|6kem]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=H1X:2-[(5-tert-butyl-2-methyl-phenyl)sulfonylamino]benzoic+acid'>H1X</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GstE14, GSTD14-14, nobo, CG4688 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7day FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7day OCA], [https://pdbe.org/7day PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7day RCSB], [https://www.ebi.ac.uk/pdbsum/7day PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7day ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7day FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7day OCA], [https://pdbe.org/7day PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7day RCSB], [https://www.ebi.ac.uk/pdbsum/7day PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7day ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>
[https://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>  
 
==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Glutathione transferase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inaba, K]]
[[Category: Inaba K]]
[[Category: Koiwai, K]]
[[Category: Koiwai K]]
[[Category: Niwa, R]]
[[Category: Niwa R]]
[[Category: Senda, T]]
[[Category: Senda T]]
[[Category: Yumoto, F]]
[[Category: Yumoto F]]
[[Category: Drosophila melanogaster]]
[[Category: Ecdysteroid]]
[[Category: Glutathione s-transferase]]
[[Category: Gst]]
[[Category: Gste14]]
[[Category: Inhibitor]]
[[Category: Transferase]]

Latest revision as of 16:29, 29 November 2023

Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP013-, and GSH-bound form

7day, resolution 1.48Å

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