7f5e: Difference between revisions
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==Crystal structure of BPTF-BRD with ligand DC-BPi-11 bound== | ==Crystal structure of BPTF-BRD with ligand DC-BPi-11 bound== | ||
<StructureSection load='7f5e' size='340' side='right'caption='[[7f5e]]' scene=''> | <StructureSection load='7f5e' size='340' side='right'caption='[[7f5e]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5E FirstGlance]. <br> | <table><tr><td colspan='2'>[[7f5e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5E FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5e OCA], [https://pdbe.org/7f5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5e RCSB], [https://www.ebi.ac.uk/pdbsum/7f5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5e ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2001712Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1IY:N,N-dimethyl-3-[5-(2-methylsulfonyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)indol-1-yl]propan-1-amine'>1IY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5e OCA], [https://pdbe.org/7f5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5e RCSB], [https://www.ebi.ac.uk/pdbsum/7f5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5e ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lu | [[Category: Lin H]] | ||
[[Category: Lu HB]] | |||
[[Category: Lu T]] | |||
[[Category: Lu W]] | |||
[[Category: Luo C]] | |||
[[Category: Wang J]] | |||
Latest revision as of 17:09, 29 November 2023
Crystal structure of BPTF-BRD with ligand DC-BPi-11 bound
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