7v62: Difference between revisions

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<StructureSection load='7v62' size='340' side='right'caption='[[7v62]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
<StructureSection load='7v62' size='340' side='right'caption='[[7v62]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7v62]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V62 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7v62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V62 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v62 OCA], [https://pdbe.org/7v62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v62 RCSB], [https://www.ebi.ac.uk/pdbsum/7v62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v62 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v62 OCA], [https://pdbe.org/7v62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v62 RCSB], [https://www.ebi.ac.uk/pdbsum/7v62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v62 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/OSBP1_HUMAN OSBP1_HUMAN]] Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.<ref>PMID:15746430</ref> <ref>PMID:18450749</ref>
[https://www.uniprot.org/uniprot/OSBP1_HUMAN OSBP1_HUMAN] Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.<ref>PMID:15746430</ref> <ref>PMID:18450749</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kato, R]]
[[Category: Kato R]]
[[Category: Kobayashi, J]]
[[Category: Kobayashi J]]
[[Category: Lipid binding protein]]
[[Category: Lipid transport]]
[[Category: Lipid transport protein]]
[[Category: Oxysterol binding protein]]
[[Category: Oxysterol binding protein-related domain]]
Retrieved from "https://proteopedia.org/7v62"