7xv7: Difference between revisions
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==Crystal structure of ZYG11B bound to ORF10 peptide== | ==Crystal structure of ZYG11B bound to ORF10 peptide== | ||
<StructureSection load='7xv7' size='340' side='right'caption='[[7xv7]]' scene=''> | <StructureSection load='7xv7' size='340' side='right'caption='[[7xv7]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XV7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7xv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XV7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xv7 OCA], [https://pdbe.org/7xv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xv7 RCSB], [https://www.ebi.ac.uk/pdbsum/7xv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xv7 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xv7 OCA], [https://pdbe.org/7xv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xv7 RCSB], [https://www.ebi.ac.uk/pdbsum/7xv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xv7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ZY11B_HUMAN ZY11B_HUMAN] Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).<ref>PMID:31273098</ref> <ref>PMID:33093214</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Dong C]] | [[Category: Dong C]] | ||
[[Category: Li Y]] | [[Category: Li Y]] | ||
[[Category: Yan X]] | [[Category: Yan X]] | ||
Latest revision as of 18:01, 29 November 2023
Crystal structure of ZYG11B bound to ORF10 peptide
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