1m2s: Difference between revisions
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==Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch== | ==Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch== | ||
<StructureSection load='1m2s' size='340' side='right'caption='[[1m2s | <StructureSection load='1m2s' size='340' side='right'caption='[[1m2s]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2S FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2S FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2s OCA], [https://pdbe.org/1m2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2s RCSB], [https://www.ebi.ac.uk/pdbsum/1m2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2s ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2s OCA], [https://pdbe.org/1m2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2s RCSB], [https://www.ebi.ac.uk/pdbsum/1m2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KA162_MESMA KA162_MESMA] Alpha-KTx 16.2: inhibits large conductance calcium-activated potassium channels (KCa1.1/Slo-beta4 KCNMA1/KCNMB4). It appears to block channel activity by a simple bimolecular inhibition process. Shows a fast association rate and a slow dissociation rate of binding on rat brain synaptosome (PubMed:18199674). Significantly inhibits voltage-dependent sodium current and voltage-dependent delayed rectifier potassium currents (PubMed:14632928).<ref>PMID:14632928</ref> <ref>PMID:18199674</ref> Martentoxin-1: significantly inhibits voltage-dependent sodium current (Nav) and voltage-dependent delayed rectifier potassium current.<ref>PMID:14632928</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
[[Category: Hu | [[Category: Hu G]] | ||
[[Category: Li | [[Category: Li M]] | ||
[[Category: Wang | [[Category: Wang Y]] | ||
[[Category: Wu | [[Category: Wu G]] | ||
[[Category: Wu | [[Category: Wu H]] | ||
[[Category: Zhang | [[Category: Zhang N]] | ||
