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==SCORPION TOXIN (MAUROTOXIN) FROM SCORPIO MAURUS, NMR, 35 STRUCTURES==
==SCORPION TOXIN (MAUROTOXIN) FROM SCORPIO MAURUS, NMR, 35 STRUCTURES==
<StructureSection load='1txm' size='340' side='right'caption='[[1txm]], [[NMR_Ensembles_of_Models | 35 NMR models]]' scene=''>
<StructureSection load='1txm' size='340' side='right'caption='[[1txm]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1txm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scorpio_maurus Scorpio maurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXM FirstGlance]. <br>
<table><tr><td colspan='2'>[[1txm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scorpio_maurus Scorpio maurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXM FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txm OCA], [https://pdbe.org/1txm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txm RCSB], [https://www.ebi.ac.uk/pdbsum/1txm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txm OCA], [https://pdbe.org/1txm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txm RCSB], [https://www.ebi.ac.uk/pdbsum/1txm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KAX62_SCOMA KAX62_SCOMA]] Blocks voltage-gated potassium channels (Shaker B, and Kv1.2/KCNA2 (IC(50)=0.8 nM)) and is also active on Kv1.1/KCNA1 (IC(50)=45 nM) Kv1.3/KCNA3 (IC(50)=180 nM). Also inhibits apamin-sensitive small conductance calcium-activated potassium (SK/KCNN) channels, and inhibits intermediate conductance calcium-activated potassium (KCa3.1/KCNN4) channels.<ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>
[https://www.uniprot.org/uniprot/KAX62_SCOPA KAX62_SCOPA] Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.12-0.8 nM), KCa3.1/KCNN4 (IC(50)=1-2.2 nM), Shaker B (IC(50)=2.39-80 nM), Kv1.1/KCNA1 (IC(50)=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC(50)=150-180 or no activity, depending on the study).<ref>PMID:10888198</ref> <ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:18042681</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Scorpio maurus]]
[[Category: Scorpio maurus]]
[[Category: Ayeb, M El]]
[[Category: Blanc E]]
[[Category: Blanc, E]]
[[Category: Darbon H]]
[[Category: Darbon, H]]
[[Category: El Ayeb M]]
[[Category: Kharrat, R]]
[[Category: Kharrat R]]
[[Category: Meunier, S]]
[[Category: Meunier S]]
[[Category: Rietschoten, J Van]]
[[Category: Sabatier J-M]]
[[Category: Sabatier, J M]]
[[Category: Van Rietschoten J]]
[[Category: Alpha beta scorpion toxin fold]]
[[Category: Neurotoxin]]
[[Category: Potassium channel blocker]]
[[Category: Scorpion]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/1txm"