1h47: Difference between revisions

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<StructureSection load='1h47' size='340' side='right'caption='[[1h47]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='1h47' size='340' side='right'caption='[[1h47]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1h47]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobb Ecobb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H47 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1h47]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H47 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gx1|1gx1]], [[1h48|1h48]], [[1jy8|1jy8]], [[1knj|1knj]], [[1knk|1knk]], [[1u3l|1u3l]], [[1u3p|1u3p]], [[1u40|1u40]], [[1u43|1u43]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=GPP:GERANYL+DIPHOSPHATE'>GPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h47 OCA], [https://pdbe.org/1h47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h47 RCSB], [https://www.ebi.ac.uk/pdbsum/1h47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h47 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h47 OCA], [https://pdbe.org/1h47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h47 RCSB], [https://www.ebi.ac.uk/pdbsum/1h47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h47 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISPF_ECOLI ISPF_ECOLI] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.<ref>PMID:10694574</ref> <ref>PMID:22839733</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
[[Category: Escherichia coli BL21]]
[[Category: Ecobb]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Alphey, M S]]
[[Category: Alphey MS]]
[[Category: Bond, C S]]
[[Category: Bond CS]]
[[Category: Hunter, W N]]
[[Category: Hunter WN]]
[[Category: Kemp, L E]]
[[Category: Kemp LE]]
[[Category: Isoprene biosynthesis]]
[[Category: Isoprenoid]]
[[Category: Lyase]]
[[Category: Synthase]]
Retrieved from "https://proteopedia.org/1h47"