1hcf: Difference between revisions

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<StructureSection load='1hcf' size='340' side='right'caption='[[1hcf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='1hcf' size='340' side='right'caption='[[1hcf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1hcf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HCF FirstGlance]. <br>
<table><tr><td colspan='2'>[[1hcf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HCF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wwb|1wwb]], [[1b8m|1b8m]], [[1b98|1b98]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hcf OCA], [https://pdbe.org/1hcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hcf RCSB], [https://www.ebi.ac.uk/pdbsum/1hcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hcf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hcf OCA], [https://pdbe.org/1hcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hcf RCSB], [https://www.ebi.ac.uk/pdbsum/1hcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hcf ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN]] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:[https://omim.org/entry/613100 613100]]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.  
[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:[https://omim.org/entry/613100 613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN]] Target-derived survival factor for peripheral sensory sympathetic neurons.  
[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN] Target-derived survival factor for peripheral sensory sympathetic neurons.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allen, S J]]
[[Category: Allen SJ]]
[[Category: Banfield, M J]]
[[Category: Banfield MJ]]
[[Category: Brady, R L]]
[[Category: Brady RL]]
[[Category: Dawbarn, D]]
[[Category: Dawbarn D]]
[[Category: Naylor, R L]]
[[Category: Naylor RL]]
[[Category: Robertson, A G.S]]
[[Category: Robertson AGS]]
[[Category: Immunoglobulin domain]]
[[Category: Neurotrophin-4/5]]
[[Category: Ngf-beta superfamily]]
[[Category: Transferase-hormone complex]]
[[Category: Transferase/hormone]]
[[Category: Trkb receptor]]
Retrieved from "https://proteopedia.org/1hcf"