1uti: Difference between revisions

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<StructureSection load='1uti' size='340' side='right'caption='[[1uti]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='1uti' size='340' side='right'caption='[[1uti]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1uti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UTI FirstGlance]. <br>
<table><tr><td colspan='2'>[[1uti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UTI FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h3h|1h3h]], [[1oeb|1oeb]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transferase Transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uti OCA], [https://pdbe.org/1uti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uti RCSB], [https://www.ebi.ac.uk/pdbsum/1uti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uti ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uti OCA], [https://pdbe.org/1uti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uti RCSB], [https://www.ebi.ac.uk/pdbsum/1uti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uti ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GRP2_MOUSE GRP2_MOUSE]] Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.<ref>PMID:9789079</ref> <ref>PMID:10777492</ref> <ref>PMID:10913189</ref> <ref>PMID:11432821</ref> <ref>PMID:11278453</ref> <ref>PMID:12239348</ref> <ref>PMID:15334074</ref> <ref>PMID:16357324</ref> <ref>PMID:17492052</ref>  [[https://www.uniprot.org/uniprot/M4K1_MOUSE M4K1_MOUSE]] May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.<ref>PMID:9003777</ref> 
[https://www.uniprot.org/uniprot/GRAP2_MOUSE GRAP2_MOUSE] Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Transferase]]
[[Category: Domart MC]]
[[Category: Domart, M C]]
[[Category: Feller SM]]
[[Category: Feller, S M]]
[[Category: Harkiolaki M]]
[[Category: Harkiolaki, M]]
[[Category: Lewitzky M]]
[[Category: Lewitzky, M]]
[[Category: Ppii helix]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain-complex]]
[[Category: Signaling protein regulator]]
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