1utt: Difference between revisions

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<StructureSection load='1utt' size='340' side='right'caption='[[1utt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1utt' size='340' side='right'caption='[[1utt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1utt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UTT FirstGlance]. <br>
<table><tr><td colspan='2'>[[1utt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UTT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CP8:2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)+ETHYL-4-(4-ETHOXY+[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC+ACID'>CP8</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jiz|1jiz]], [[1jk3|1jk3]], [[1os2|1os2]], [[1os9|1os9]], [[1ros|1ros]], [[1utz|1utz]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CP8:2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)+ETHYL-4-(4-ETHOXY+[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC+ACID'>CP8</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1utt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1utt OCA], [https://pdbe.org/1utt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1utt RCSB], [https://www.ebi.ac.uk/pdbsum/1utt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1utt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1utt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1utt OCA], [http://pdbe.org/1utt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1utt RCSB], [http://www.ebi.ac.uk/pdbsum/1utt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1utt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.  
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Macrophage elastase]]
[[Category: Beltra J]]
[[Category: Beltra, J]]
[[Category: Compere D]]
[[Category: Compere, D]]
[[Category: De Mendez I]]
[[Category: Dublanchet, A C]]
[[Category: Dublanchet AC]]
[[Category: Dufour, S]]
[[Category: Dufour S]]
[[Category: Florent, J M]]
[[Category: Florent JM]]
[[Category: Gara, M O]]
[[Category: Manceau P]]
[[Category: Manceau, P]]
[[Category: Morales R]]
[[Category: Mendez, I De]]
[[Category: Moreau F]]
[[Category: Morales, R]]
[[Category: O'Gara M]]
[[Category: Moreau, F]]
[[Category: Perrier S]]
[[Category: Perrier, S]]
[[Category: Tertre A]]
[[Category: Tertre, A]]
[[Category: Hydrolase]]
[[Category: Macrophage metalloelastase]]
[[Category: Metalloprotease]]
[[Category: Mmp inhibitor]]
[[Category: Mmp-12]]
[[Category: Non-zinc chelator]]
Retrieved from "https://proteopedia.org/1utt"