2c6s: Difference between revisions
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<StructureSection load='2c6s' size='340' side='right'caption='[[2c6s]], [[Resolution|resolution]] 3.60Å' scene=''> | <StructureSection load='2c6s' size='340' side='right'caption='[[2c6s]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c6s]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2c6s]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C6S FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6s OCA], [https://pdbe.org/2c6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c6s RCSB], [https://www.ebi.ac.uk/pdbsum/2c6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c6s ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6s OCA], [https://pdbe.org/2c6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c6s RCSB], [https://www.ebi.ac.uk/pdbsum/2c6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c6s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CAPSP_ADE02 CAPSP_ADE02] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.<ref>PMID:12221069</ref> <ref>PMID:20615244</ref> <ref>PMID:20798312</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human adenovirus 2]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blanchoin | [[Category: Blanchoin L]] | ||
[[Category: Cusack | [[Category: Cusack S]] | ||
[[Category: Zubieta | [[Category: Zubieta C]] | ||
