2caq: Difference between revisions

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<StructureSection load='2caq' size='340' side='right'caption='[[2caq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2caq' size='340' side='right'caption='[[2caq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2caq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CAQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2caq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CAQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c80|2c80]], [[2c8u|2c8u]], [[2cai|2cai]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2caq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2caq OCA], [https://pdbe.org/2caq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2caq RCSB], [https://www.ebi.ac.uk/pdbsum/2caq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2caq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2caq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2caq OCA], [https://pdbe.org/2caq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2caq RCSB], [https://www.ebi.ac.uk/pdbsum/2caq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2caq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.  
[https://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Blood fluke]]
[[Category: Glutathione transferase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Angelucci, F]]
[[Category: Schistosoma haematobium]]
[[Category: Baiocco, P]]
[[Category: Angelucci F]]
[[Category: Bellelli, A]]
[[Category: Baiocco P]]
[[Category: Brunori, M]]
[[Category: Bellelli A]]
[[Category: Gourlay, L J]]
[[Category: Brunori M]]
[[Category: Miele, A E]]
[[Category: Gourlay LJ]]
[[Category: Antigen]]
[[Category: Miele AE]]
[[Category: Detoxification]]
[[Category: Glutathione]]
[[Category: Prostaglandin d2 synthase]]
[[Category: Sigma class gst]]
[[Category: Transferase]]
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