2ixp: Difference between revisions
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<StructureSection load='2ixp' size='340' side='right'caption='[[2ixp]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='2ixp' size='340' side='right'caption='[[2ixp]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ixp]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ixp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene>, <scene name='pdbligand=PRD_000352:N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-L-prolyl-6-ammonio-N-(4-nitrophenyl)-L-norleucinamide'>PRD_000352</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixp OCA], [https://pdbe.org/2ixp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixp RCSB], [https://www.ebi.ac.uk/pdbsum/2ixp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixp ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PTPA1_YEAST PTPA1_YEAST] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Involved in the regulation of cell cycle progression, mitotic spindle formation, bud morphogenesis and DNA repair.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15150670</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Barford | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Goris | [[Category: Synthetic construct]] | ||
[[Category: Jordens | [[Category: Barford D]] | ||
[[Category: Leulliot | [[Category: Goris J]] | ||
[[Category: Quevillon-Cheruel | [[Category: Jordens J]] | ||
[[Category: Schiltz | [[Category: Leulliot N]] | ||
[[Category: Tilbeurgh | [[Category: Quevillon-Cheruel S]] | ||
[[Category: Vicentini | [[Category: Schiltz M]] | ||
[[Category: Van Tilbeurgh H]] | |||
[[Category: Vicentini G]] | |||
