2j4t: Difference between revisions

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<StructureSection load='2j4t' size='340' side='right'caption='[[2j4t]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
<StructureSection load='2j4t' size='340' side='right'caption='[[2j4t]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4T FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4T FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4t OCA], [https://pdbe.org/2j4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4t RCSB], [https://www.ebi.ac.uk/pdbsum/2j4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4t OCA], [https://pdbe.org/2j4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4t RCSB], [https://www.ebi.ac.uk/pdbsum/2j4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ANG4_MOUSE ANG4_MOUSE]] Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro).<ref>PMID:12548285</ref> <ref>PMID:17279775</ref>
[https://www.uniprot.org/uniprot/ANG4_MOUSE ANG4_MOUSE] Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro).<ref>PMID:12548285</ref> <ref>PMID:17279775</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2j4t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2j4t" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Acharya KR]]
[[Category: Acharya, K R]]
[[Category: Baker MD]]
[[Category: Baker, M D]]
[[Category: Crabtree B]]
[[Category: Crabtree, B]]
[[Category: Holloway DE]]
[[Category: Holloway, D E]]
[[Category: Subramanian V]]
[[Category: Subramanian, V]]
[[Category: Angiogenesis]]
[[Category: Cancer]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Nuclease]]
[[Category: Protein synthesis inhibitor]]
[[Category: Pyrrolidone carboxylic acid]]
[[Category: Ribonuclease]]
Retrieved from "https://proteopedia.org/2j4t"