2j8b: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='2j8b' size='340' side='right'caption='[[2j8b]], [[Resolution|resolution]] 1.15Å' scene=''> | <StructureSection load='2j8b' size='340' side='right'caption='[[2j8b]], [[Resolution|resolution]] 1.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2j8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2j8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8B FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8b OCA], [https://pdbe.org/2j8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8b RCSB], [https://www.ebi.ac.uk/pdbsum/2j8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8b ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8b OCA], [https://pdbe.org/2j8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8b RCSB], [https://www.ebi.ac.uk/pdbsum/2j8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8b ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[https://omim.org/entry/612300 612300].<ref>PMID:1382994</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 37: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Johnson | [[Category: Johnson S]] | ||
[[Category: Lea | [[Category: Lea SM]] | ||
[[Category: Leath | [[Category: Leath KJ]] | ||
[[Category: Morgan | [[Category: Morgan BP]] | ||
[[Category: Roversi | [[Category: Roversi P]] | ||
[[Category: Smith | [[Category: Smith RAG]] | ||
