2jc6: Difference between revisions

Latest revision as of 14:42, 13 December 2023

Crystal structure of human calmodulin-dependent protein kinase 1D

Structural highlights

2jc6 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Ligands:	QPP
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.^[1] ^[2] ^[3] ^[4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Verploegen S, Lammers JW, Koenderman L, Coffer PJ. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood. 2000 Nov 1;96(9):3215-23. PMID:11050006
↑ Verploegen S, Ulfman L, van Deutekom HW, van Aalst C, Honing H, Lammers JW, Koenderman L, Coffer PJ. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood. 2005 Aug 1;106(3):1076-83. Epub 2005 Apr 19. PMID:15840691 doi:https://dx.doi.org/10.1182/blood-2004-09-3755
↑ Sakagami H, Kamata A, Nishimura H, Kasahara J, Owada Y, Takeuchi Y, Watanabe M, Fukunaga K, Kondo H. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Eur J Neurosci. 2005 Dec;22(11):2697-707. PMID:16324104 doi:https://dx.doi.org/10.1111/j.1460-9568.2005.04463.x
↑ Kamata A, Sakagami H, Tokumitsu H, Owada Y, Fukunaga K, Kondo H. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res. 2007 Jan;57(1):86-97. Epub 2006 Oct 23. PMID:17056143 doi:https://dx.doi.org/10.1016/j.neures.2006.09.013

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OCA

[1] Verploegen S, Lammers JW, Koenderman L, Coffer PJ. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood. 2000 Nov 1;96(9):3215-23. PMID:11050006

[2] Verploegen S, Ulfman L, van Deutekom HW, van Aalst C, Honing H, Lammers JW, Koenderman L, Coffer PJ. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood. 2005 Aug 1;106(3):1076-83. Epub 2005 Apr 19. PMID:15840691 doi:https://dx.doi.org/10.1182/blood-2004-09-3755

[3] Sakagami H, Kamata A, Nishimura H, Kasahara J, Owada Y, Takeuchi Y, Watanabe M, Fukunaga K, Kondo H. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Eur J Neurosci. 2005 Dec;22(11):2697-707. PMID:16324104 doi:https://dx.doi.org/10.1111/j.1460-9568.2005.04463.x

[4] Kamata A, Sakagami H, Tokumitsu H, Owada Y, Fukunaga K, Kondo H. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res. 2007 Jan;57(1):86-97. Epub 2006 Oct 23. PMID:17056143 doi:https://dx.doi.org/10.1016/j.neures.2006.09.013

[1]

[2]

[3]

[4]

@@ Line 3: / Line 3: @@
 <StructureSection load='2jc6' size='340' side='right'caption='[[2jc6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC6 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QPP:N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE'>QPP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QPP:N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE'>QPP</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc6 OCA], [https://pdbe.org/2jc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc6 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN]] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
+[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 27: @@
 __TOC__
 </StructureSection>
-[[Category: Calcium/calmodulin-dependent protein kinase]]
+[[Category: Homo sapiens]]
-[[Category: Human]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Berridge, G]]
+[[Category: Berridge G]]
-[[Category: Bhatia, C]]
+[[Category: Bhatia C]]
-[[Category: Bunkoczi, G]]
+[[Category: Bunkoczi G]]
-[[Category: Colebrook, S]]
+[[Category: Colebrook S]]
-[[Category: Debreczeni, J E]]
+[[Category: Debreczeni JE]]
-[[Category: Delft, F von]]
+[[Category: Edwards A]]
-[[Category: Edwards, A]]
+[[Category: Fedorov O]]
-[[Category: Fedorov, O]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O]]
+[[Category: Knapp S]]
-[[Category: Knapp, S]]
+[[Category: Niesen FH]]
-[[Category: Niesen, F H]]
+[[Category: Pike ACW]]
-[[Category: Pike, A C.W]]
+[[Category: Rellos P]]
-[[Category: Rellos, P]]
+[[Category: Salah E]]
-[[Category: Salah, E]]
+[[Category: Shrestha L]]
-[[Category: Shrestha, L]]
+[[Category: Smee C]]
-[[Category: Smee, C]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M]]
+[[Category: Ugochukwu E]]
-[[Category: Ugochukwu, E]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J]]
+[[Category: Von Delft F]]
-[[Category: Atp-binding]]
-[[Category: Nuclear protein]]
-[[Category: Phosphorylation]]
-[[Category: Transferase]]

2jc6: Difference between revisions

Latest revision as of 14:42, 13 December 2023

Crystal structure of human calmodulin-dependent protein kinase 1D

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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