2jht: Difference between revisions
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<StructureSection load='2jht' size='340' side='right'caption='[[2jht]], [[Resolution|resolution]] 1.88Å' scene=''> | <StructureSection load='2jht' size='340' side='right'caption='[[2jht]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2jht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHT FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jht OCA], [https://pdbe.org/2jht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jht RCSB], [https://www.ebi.ac.uk/pdbsum/2jht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jht ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jht OCA], [https://pdbe.org/2jht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jht RCSB], [https://www.ebi.ac.uk/pdbsum/2jht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jht ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cooper | [[Category: Cooper DR]] | ||
[[Category: Derewenda | [[Category: Derewenda ZS]] | ||
[[Category: Grelewska | [[Category: Grelewska K]] | ||
