2vlw: Difference between revisions

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<StructureSection load='2vlw' size='340' side='right'caption='[[2vlw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
<StructureSection load='2vlw' size='340' side='right'caption='[[2vlw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vlw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VLW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VLW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYI:3,5-DIIODOTYROSINE'>TYI</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TYI:3,5-DIIODOTYROSINE'>TYI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlw OCA], [https://pdbe.org/2vlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vlw RCSB], [https://www.ebi.ac.uk/pdbsum/2vlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vlw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlw OCA], [https://pdbe.org/2vlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vlw RCSB], [https://www.ebi.ac.uk/pdbsum/2vlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vlw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NXM11_DENAN NXM11_DENAN]] Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.<ref>PMID:11562434</ref> <ref>PMID:10799315</ref>
[https://www.uniprot.org/uniprot/3SIM7_DENAN 3SIM7_DENAN] Binds irreversibly and specifically to an allosteric site of the muscarinic acetylcholine M1 receptor (CHRM1).<ref>PMID:10799315</ref> <ref>PMID:11562434</ref> <ref>PMID:12488533</ref> <ref>PMID:21557730</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dendroaspis angusticeps]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fruchart-Gaillard, C]]
[[Category: Fruchart-Gaillard C]]
[[Category: Granata, V]]
[[Category: Granata V]]
[[Category: Menez, A]]
[[Category: Menez A]]
[[Category: Menez, R]]
[[Category: Menez R]]
[[Category: Mourier, G]]
[[Category: Mourier G]]
[[Category: Servant, D]]
[[Category: Servant D]]
[[Category: Stura, E A]]
[[Category: Stura EA]]
[[Category: Acetylcholine receptor inhibitor]]
[[Category: Diiodotyrosine]]
[[Category: Green mamba snake toxin]]
[[Category: Hm1 muscarinic receptor]]
[[Category: Muscarinic toxin]]
[[Category: Neurotoxin]]
[[Category: Postsynaptic neurotoxin]]
[[Category: Secreted]]
[[Category: Toxin]]