2vna: Difference between revisions

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<StructureSection load='2vna' size='340' side='right'caption='[[2vna]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
<StructureSection load='2vna' size='340' side='right'caption='[[2vna]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w4q|2w4q]], [[2w98|2w98]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/15-oxoprostaglandin_13-oxidase 15-oxoprostaglandin 13-oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.48 1.3.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vna OCA], [https://pdbe.org/2vna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vna RCSB], [https://www.ebi.ac.uk/pdbsum/2vna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vna ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vna OCA], [https://pdbe.org/2vna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vna RCSB], [https://www.ebi.ac.uk/pdbsum/2vna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vna ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTGR2_HUMAN PTGR2_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).<ref>PMID:19000823</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 15-oxoprostaglandin 13-oxidase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Fedorov O]]
[[Category: Fedorov, O]]
[[Category: Johansson C]]
[[Category: Johansson, C]]
[[Category: Kavanagh K]]
[[Category: Kavanagh, K]]
[[Category: Kochan G]]
[[Category: Kochan, G]]
[[Category: Muniz JRC]]
[[Category: Muniz, J R.C]]
[[Category: Opperman U]]
[[Category: Opperman, U]]
[[Category: Picaud S]]
[[Category: Picaud, S]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Pilka E]]
[[Category: Pilka, E]]
[[Category: Roos AK]]
[[Category: Roos, A K]]
[[Category: Shafqat N]]
[[Category: Shafqat, N]]
[[Category: Smee C]]
[[Category: Smee, C]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Von Delft F]]
[[Category: Alternative splicing]]
[[Category: Cytoplasm]]
[[Category: Dehydrogenase prostaglandin reductase zinc-binding 5- oxop nadp]]
[[Category: Oxidoreductase]]

Latest revision as of 15:25, 13 December 2023

Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1)

2vna, resolution 2.17Å

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