2vr2: Difference between revisions

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<StructureSection load='2vr2' size='340' side='right'caption='[[2vr2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2vr2' size='340' side='right'caption='[[2vr2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydropyrimidinase Dihydropyrimidinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.2 3.5.2.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr2 OCA], [https://pdbe.org/2vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr2 OCA], [https://pdbe.org/2vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Dihydropyrimidinuria. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydropyrimidinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Andersson, J]]
[[Category: Andersson J]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S Van Den]]
[[Category: Berglund H]]
[[Category: Berglund, H]]
[[Category: Busam RD]]
[[Category: Busam, R D]]
[[Category: Collins R]]
[[Category: Collins, R]]
[[Category: Dahlgren LG]]
[[Category: Dahlgren, L G]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Flodin S]]
[[Category: Flodin, S]]
[[Category: Flores A]]
[[Category: Flores, A]]
[[Category: Graslund S]]
[[Category: Graslund, S]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M]]
[[Category: Herman MD]]
[[Category: Herman, M D]]
[[Category: Johansson I]]
[[Category: Johansson, I]]
[[Category: Kallas A]]
[[Category: Kallas, A]]
[[Category: Karlberg T]]
[[Category: Karlberg, T]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T]]
[[Category: Lehtio L]]
[[Category: Lehtio, L]]
[[Category: Moche M]]
[[Category: Moche, M]]
[[Category: Nilsson ME]]
[[Category: Nilsson, M E]]
[[Category: Nordlund P]]
[[Category: Nordlund, P]]
[[Category: Nyman T]]
[[Category: Nyman, T]]
[[Category: Persson C]]
[[Category: Persson, C]]
[[Category: Sagemark J]]
[[Category: Structural genomic]]
[[Category: Svensson L]]
[[Category: Sagemark, J]]
[[Category: Thorsell AG]]
[[Category: Svensson, L]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G]]
[[Category: Van Den Berg S]]
[[Category: Tresaugues, L]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Welin M]]
[[Category: Welin, M]]
[[Category: Wikstrom M]]
[[Category: Wikstrom, M]]
[[Category: Dhp]]
[[Category: Dhpase]]
[[Category: Dihydropyrimidine amidohydrolase]]
[[Category: Disease mutation]]
[[Category: Dpy]]
[[Category: Hydantoinase]]
[[Category: Hydrolase]]
[[Category: Metal-binding]]
[[Category: Nucleotide metabolism]]
[[Category: Zn-binding]]

Latest revision as of 15:29, 13 December 2023

Human Dihydropyrimidinase

2vr2, resolution 2.80Å

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