2vwf: Difference between revisions

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<StructureSection load='2vwf' size='340' side='right'caption='[[2vwf]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
<StructureSection load='2vwf' size='340' side='right'caption='[[2vwf]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vwf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VWF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vwf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VWF FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h46|2h46]], [[1qg1|1qg1]], [[1cj1|1cj1]], [[1bm2|1bm2]], [[1gfd|1gfd]], [[1fyr|1fyr]], [[1jyu|1jyu]], [[1bmb|1bmb]], [[1jyq|1jyq]], [[1gfc|1gfc]], [[2aob|2aob]], [[1x0n|1x0n]], [[1tze|1tze]], [[1aze|1aze]], [[1gri|1gri]], [[2vvk|2vvk]], [[1io6|1io6]], [[1fhs|1fhs]], [[1zfp|1zfp]], [[1gcq|1gcq]], [[1ghu|1ghu]], [[2aoa|2aoa]], [[1jyr|1jyr]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwf OCA], [https://pdbe.org/2vwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vwf RCSB], [https://www.ebi.ac.uk/pdbsum/2vwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vwf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwf OCA], [https://pdbe.org/2vwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vwf RCSB], [https://www.ebi.ac.uk/pdbsum/2vwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vwf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GAB2_HUMAN GAB2_HUMAN]] Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.<ref>PMID:15750601</ref> <ref>PMID:19172738</ref>
[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>  Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Feller, S M]]
[[Category: Feller SM]]
[[Category: Harkiolaki, M]]
[[Category: Harkiolaki M]]
[[Category: Tsirka, T]]
[[Category: Tsirka T]]
[[Category: Alternative splicing]]
[[Category: Golgi apparatus]]
[[Category: Grb2]]
[[Category: Host-virus interaction]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein binding]]
[[Category: Protein-binding]]
[[Category: Sh2 domain]]
[[Category: Sh3 domain]]
[[Category: Sh3c]]
[[Category: Signaling]]
Retrieved from "https://proteopedia.org/2vwf"