2vz6: Difference between revisions

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<StructureSection load='2vz6' size='340' side='right'caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2vz6' size='340' side='right'caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [https://pdbe.org/2vz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [https://pdbe.org/2vz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCC2A_HUMAN KCC2A_HUMAN] CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Calcium/calmodulin-dependent protein kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Fedorov O]]
[[Category: Fedorov, O]]
[[Category: King O]]
[[Category: King, O]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Murray JW]]
[[Category: Murray, J W]]
[[Category: Parizotto E]]
[[Category: Parizotto, E]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Rellos P]]
[[Category: Rellos, P]]
[[Category: Roos A]]
[[Category: Roos, A]]
[[Category: Salah E]]
[[Category: Salah, E]]
[[Category: Shrestha L]]
[[Category: Shrestha, L]]
[[Category: Wikstroem M]]
[[Category: Wikstroem, M]]
[[Category: Von Delft F]]
[[Category: Atp-binding]]
[[Category: Brain]]
[[Category: Calmodulin-binding]]
[[Category: Cell junction]]
[[Category: Cell membrane]]
[[Category: Kinase]]
[[Category: Long term potentiation]]
[[Category: Membrane]]
[[Category: Nmda receptor signalling]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Synapse]]
[[Category: Transferase]]
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