2wah: Difference between revisions

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<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e4k|1e4k]], [[1t83|1t83]], [[1h3u|1h3u]], [[1h3v|1h3v]], [[1oqx|1oqx]], [[1fc1|1fc1]], [[2rcs|2rcs]], [[1aqk|1aqk]], [[2iwg|2iwg]], [[1d5b|1d5b]], [[1d5i|1d5i]], [[1i7z|1i7z]], [[2j6e|2j6e]], [[1h3y|1h3y]], [[1d6v|1d6v]], [[1fcc|1fcc]], [[1h3w|1h3w]], [[1dn2|1dn2]], [[1t89|1t89]], [[1h3t|1h3t]], [[1aj7|1aj7]], [[1l6x|1l6x]], [[1bey|1bey]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [https://pdbe.org/2wah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [https://www.ebi.ac.uk/pdbsum/2wah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [https://pdbe.org/2wah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [https://www.ebi.ac.uk/pdbsum/2wah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.  
[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
== Function ==
[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aricescu, A R]]
[[Category: Aricescu AR]]
[[Category: Bowden, T A]]
[[Category: Bowden TA]]
[[Category: Coles, C H]]
[[Category: Coles CH]]
[[Category: Crispin, M]]
[[Category: Crispin M]]
[[Category: Harlos, K]]
[[Category: Harlos K]]
[[Category: Harvey, D J]]
[[Category: Harvey DJ]]
[[Category: Jones, E Y]]
[[Category: Jones EY]]
[[Category: Stuart, D I]]
[[Category: Stuart DI]]
[[Category: Antibody]]
[[Category: Antibody engineering]]
[[Category: Glycoprotein]]
[[Category: Glycosylation]]
[[Category: Immune system]]
[[Category: Immunoglobulin c region]]
[[Category: Immunoglobulin domain]]
[[Category: Kifunensine]]
[[Category: Oligomannose]]
[[Category: Secreted]]

Latest revision as of 15:49, 13 December 2023

Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2)

2wah, resolution 2.51Å

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