2whw: Difference between revisions

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<StructureSection load='2whw' size='340' side='right'caption='[[2whw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2whw' size='340' side='right'caption='[[2whw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2whw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/As_4.1526 As 4.1526]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WHW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2whw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WHW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1D4:CYCLOTRIDECYL+3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSIDE'>1D4</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cd8|2cd8]], [[2wi9|2wi9]], [[2ca0|2ca0]], [[2bvj|2bvj]], [[2vzm|2vzm]], [[2c7x|2c7x]], [[2vz7|2vz7]], [[2c6h|2c6h]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1D4:CYCLOTRIDECYL+3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSIDE'>1D4</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whw OCA], [https://pdbe.org/2whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2whw RCSB], [https://www.ebi.ac.uk/pdbsum/2whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2whw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whw OCA], [https://pdbe.org/2whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2whw RCSB], [https://www.ebi.ac.uk/pdbsum/2whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2whw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: As 4 1526]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chaulagain, M R]]
[[Category: Streptomyces venezuelae]]
[[Category: Knauff, A R]]
[[Category: Chaulagain MR]]
[[Category: Li, S]]
[[Category: Knauff AR]]
[[Category: Montgomery, J]]
[[Category: Li S]]
[[Category: Podust, L M]]
[[Category: Montgomery J]]
[[Category: Sherman, D H]]
[[Category: Podust LM]]
[[Category: Antibiotic biosynthesis]]
[[Category: Sherman DH]]
[[Category: Cyp107l1]]
[[Category: Cytochrome p450]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Macrolide monooxygenase]]
[[Category: Metal-binding]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase antibiotic biosynthesis]]
[[Category: Pikc]]
Retrieved from "https://proteopedia.org/2whw"