2wk6: Difference between revisions

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<StructureSection load='2wk6' size='340' side='right'caption='[[2wk6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2wk6' size='340' side='right'caption='[[2wk6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WK6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WK6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUR:5-IODOURACIL'>IUR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j0f|2j0f]], [[2wk5|2wk5]], [[1uou|1uou]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUR:5-IODOURACIL'>IUR</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wk6 OCA], [https://pdbe.org/2wk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wk6 RCSB], [https://www.ebi.ac.uk/pdbsum/2wk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wk6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wk6 OCA], [https://pdbe.org/2wk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wk6 RCSB], [https://www.ebi.ac.uk/pdbsum/2wk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wk6 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/TYPH_HUMAN TYPH_HUMAN]] Mitochondrial neurogastrointestinal encephalomyopathy. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9924029</ref> <ref>PMID:12177387</ref>
[https://www.uniprot.org/uniprot/TYPH_HUMAN TYPH_HUMAN] Mitochondrial neurogastrointestinal encephalomyopathy. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9924029</ref> <ref>PMID:12177387</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TYPH_HUMAN TYPH_HUMAN]] May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.<ref>PMID:1590793</ref>  Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.<ref>PMID:1590793</ref>
[https://www.uniprot.org/uniprot/TYPH_HUMAN TYPH_HUMAN] May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.<ref>PMID:1590793</ref>  Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.<ref>PMID:1590793</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thymidine phosphorylase]]
[[Category: Acharya KR]]
[[Category: Acharya, K R]]
[[Category: Finnis C]]
[[Category: Finnis, C]]
[[Category: Iyer S]]
[[Category: Iyer, S]]
[[Category: Mitsiki E]]
[[Category: Mitsiki, E]]
[[Category: Papageorgiou AC]]
[[Category: Papageorgiou, A C]]
[[Category: Prior SH]]
[[Category: Prior, S H]]
[[Category: Sleep D]]
[[Category: Sleep, D]]
[[Category: Thiyagarajan N]]
[[Category: Thiyagarajan, N]]
[[Category: 5-iodouracil]]
[[Category: Angiogenesis]]
[[Category: Chemotaxis]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Disease mutation]]
[[Category: Enzyme kinetic]]
[[Category: Glycosyltransferase]]
[[Category: Growth factor]]
[[Category: Mutagenesis]]
[[Category: Polymorphism]]
[[Category: Transferase]]
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