2wls: Difference between revisions

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<StructureSection load='2wls' size='340' side='right'caption='[[2wls]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2wls' size='340' side='right'caption='[[2wls]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=X13:N,N,N-TRIMETHYL-13-[(METHYLSULFONYL)SULFANYL]TRIDECAN-1-AMINIUM'>X13</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jgh|2jgh]], [[2whq|2whq]], [[1mah|1mah]], [[2ha6|2ha6]], [[1maa|1maa]], [[2c0q|2c0q]], [[2jgg|2jgg]], [[2jgl|2jgl]], [[1q84|1q84]], [[2jgm|2jgm]], [[2jge|2jge]], [[1q83|1q83]], [[2ha3|2ha3]], [[1c2b|1c2b]], [[2ha0|2ha0]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2jgj|2jgj]], [[1j06|1j06]], [[2jf0|2jf0]], [[2c0p|2c0p]], [[2h9y|2h9y]], [[2whr|2whr]], [[1n5m|1n5m]], [[2ha5|2ha5]], [[2ha2|2ha2]], [[2whp|2whp]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2ha7|2ha7]], [[2jgf|2jgf]], [[1c2o|1c2o]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=X13:N,N,N-TRIMETHYL-13-[(METHYLSULFONYL)SULFANYL]TRIDECAN-1-AMINIUM'>X13</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wls OCA], [https://pdbe.org/2wls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wls RCSB], [https://www.ebi.ac.uk/pdbsum/2wls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wls ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wls OCA], [https://pdbe.org/2wls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wls RCSB], [https://www.ebi.ac.uk/pdbsum/2wls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wls ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.  
[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetylcholinesterase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Andersson, B]]
[[Category: Andersson B]]
[[Category: Andersson, P O]]
[[Category: Andersson PO]]
[[Category: Brimijoin, S]]
[[Category: Brimijoin S]]
[[Category: Ekstrom, F]]
[[Category: Ekstrom F]]
[[Category: Fallon, A M]]
[[Category: Fallon AM]]
[[Category: Gao, Y]]
[[Category: Gao Y]]
[[Category: Hua, D H]]
[[Category: Hua DH]]
[[Category: Mishra, R K]]
[[Category: Mishra RK]]
[[Category: Pang, Y P]]
[[Category: Pang YP]]
[[Category: Peng, L]]
[[Category: Peng L]]
[[Category: Polsinelli, G A]]
[[Category: Polsinelli GA]]
[[Category: Ragsdale, D W]]
[[Category: Ragsdale DW]]
[[Category: Rana, S]]
[[Category: Rana S]]
[[Category: Singh, S K]]
[[Category: Singh SK]]
[[Category: Zhu, K Y]]
[[Category: Zhu KY]]
[[Category: Alternative splicing]]
[[Category: Amts13]]
[[Category: Cell junction]]
[[Category: Cell membrane]]
[[Category: Cholinesterase]]
[[Category: Glycoprotein]]
[[Category: Gpi-anchor]]
[[Category: Hydrolase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Neurotransmitter degradation]]
[[Category: Serine esterase]]
[[Category: Synapse]]
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