2wng: Difference between revisions
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<StructureSection load='2wng' size='340' side='right'caption='[[2wng]], [[Resolution|resolution]] 2.49Å' scene=''> | <StructureSection load='2wng' size='340' side='right'caption='[[2wng]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2wng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNG FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wng OCA], [https://pdbe.org/2wng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wng RCSB], [https://www.ebi.ac.uk/pdbsum/2wng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wng ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wng OCA], [https://pdbe.org/2wng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wng RCSB], [https://www.ebi.ac.uk/pdbsum/2wng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wng ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SHPS1_HUMAN SHPS1_HUMAN] Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.<ref>PMID:10469599</ref> <ref>PMID:11509594</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Barclay | [[Category: Barclay AN]] | ||
[[Category: Graham | [[Category: Graham SC]] | ||
[[Category: Harlos | [[Category: Harlos K]] | ||
[[Category: Hatherley | [[Category: Hatherley D]] | ||
[[Category: Stuart | [[Category: Stuart DI]] | ||
