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==Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25==
==Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25==
<StructureSection load='5ojm' size='340' side='right' caption='[[5ojm]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='5ojm' size='340' side='right'caption='[[5ojm]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ojm]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OJM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ojm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OJM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABRA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ojm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojm OCA], [http://pdbe.org/5ojm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ojm RCSB], [http://www.ebi.ac.uk/pdbsum/5ojm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ojm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojm OCA], [https://pdbe.org/5ojm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ojm RCSB], [https://www.ebi.ac.uk/pdbsum/5ojm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.[https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Camelus glama]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Lama glama]]
[[Category: Aricescu, A R]]
[[Category: Large Structures]]
[[Category: Colibus, L De]]
[[Category: Synthetic construct]]
[[Category: Masiulis, S]]
[[Category: Aricescu AR]]
[[Category: Miller, P S]]
[[Category: De Colibus L]]
[[Category: Pardon, E]]
[[Category: Masiulis S]]
[[Category: Scott, S]]
[[Category: Miller PS]]
[[Category: Steyaert, J]]
[[Category: Pardon E]]
[[Category: Gabaa receptor]]
[[Category: Scott S]]
[[Category: Ion channel]]
[[Category: Steyaert J]]
[[Category: Membrane protein]]
[[Category: Nanobody complex]]
[[Category: Neurosteroid]]
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