8p44: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "8p44" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1202D== | |||
<StructureSection load='8p44' size='340' side='right'caption='[[8p44]], [[Resolution|resolution]] 1.93Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8p44]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P44 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WY8:9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one'>WY8</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p44 OCA], [https://pdbe.org/8p44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p44 RCSB], [https://www.ebi.ac.uk/pdbsum/8p44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p44 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/POXIN_MONPV POXIN_MONPV] Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Monkeypox virus]] | |||
[[Category: Boura E]] | |||
[[Category: Duchoslav V]] | |||
[[Category: Klima M]] | |||
Latest revision as of 10:03, 20 December 2023
Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1202D
| ||||||||||||
