2jod: Difference between revisions

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==Pac1-Rshort N-terminal EC domain Pacap(6-38) complex==
==Pac1-Rshort N-terminal EC domain Pacap(6-38) complex==
<StructureSection load='2jod' size='340' side='right'caption='[[2jod]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2jod' size='340' side='right'caption='[[2jod]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jod]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JOD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jod]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JOD FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADCYAP1R1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ADCYAP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jod OCA], [https://pdbe.org/2jod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jod RCSB], [https://www.ebi.ac.uk/pdbsum/2jod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jod ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jod OCA], [https://pdbe.org/2jod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jod RCSB], [https://www.ebi.ac.uk/pdbsum/2jod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PACR_HUMAN PACR_HUMAN]] This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. [[https://www.uniprot.org/uniprot/PACA_HUMAN PACA_HUMAN]] Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.<ref>PMID:11175907</ref> 
[https://www.uniprot.org/uniprot/PACR_HUMAN PACR_HUMAN] This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barrett, L W]]
[[Category: Barrett LW]]
[[Category: Davis-Taber, R A]]
[[Category: Davis-Taber RA]]
[[Category: Hajduk, P J]]
[[Category: Hajduk PJ]]
[[Category: Lake, M R]]
[[Category: Lake MR]]
[[Category: Olejniczak, E T]]
[[Category: Olejniczak ET]]
[[Category: Pereda-lopez, A]]
[[Category: Pereda-lopez A]]
[[Category: Richardson, P L]]
[[Category: Richardson PL]]
[[Category: Scott, V E]]
[[Category: Scott VE]]
[[Category: Solomon, L R]]
[[Category: Solomon LR]]
[[Category: Song, D]]
[[Category: Song D]]
[[Category: Sun, C]]
[[Category: Sun C]]
[[Category: Uchic, M E]]
[[Category: Uchic ME]]
[[Category: Walter, K A]]
[[Category: Walter KA]]
[[Category: Protein-peptide complex]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/2jod"