2wul: Difference between revisions

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<StructureSection load='2wul' size='340' side='right'caption='[[2wul]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2wul' size='340' side='right'caption='[[2wul]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wul]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wem 2wem]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WUL FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wul]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wem 2wem]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WUL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wul OCA], [https://pdbe.org/2wul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wul RCSB], [https://www.ebi.ac.uk/pdbsum/2wul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wul ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wul OCA], [https://pdbe.org/2wul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wul RCSB], [https://www.ebi.ac.uk/pdbsum/2wul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wul ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GLRX5_HUMAN GLRX5_HUMAN] Adult-onset autosomal recessive sideroblastic anemia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/GLRX5_HUMAN GLRX5_HUMAN] Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad A]]
[[Category: Cooper, C D.O]]
[[Category: Cooper CDO]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Guo K]]
[[Category: Guo, K]]
[[Category: Johansson C]]
[[Category: Johansson, C]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K L]]
[[Category: Oppermann U]]
[[Category: Oppermann, U]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Pilka ES]]
[[Category: Pilka, E S]]
[[Category: Roos AK]]
[[Category: Roos, A K]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Yue WW]]
[[Category: Yue, W W]]
[[Category: Von Delft F]]
[[Category: Chromosome 14 open reading frame 87]]
[[Category: Flb4739]]
[[Category: Glrx5]]
[[Category: Oxidoreductase]]
[[Category: Pr01238]]
[[Category: Thioredoxin family]]
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