2x0x: Difference between revisions

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<StructureSection load='2x0x' size='340' side='right'caption='[[2x0x]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2x0x' size='340' side='right'caption='[[2x0x]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x0x]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X0X FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x0x]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X0X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rsr|1rsr]], [[1r1r|1r1r]], [[1av8|1av8]], [[1mxr|1mxr]], [[1xik|1xik]], [[3r1r|3r1r]], [[7r1r|7r1r]], [[2av8|2av8]], [[1mrr|1mrr]], [[1pim|1pim]], [[1rib|1rib]], [[1rnr|1rnr]], [[1jqc|1jqc]], [[1qfn|1qfn]], [[2r1r|2r1r]], [[4r1r|4r1r]], [[1jpr|1jpr]], [[5r1r|5r1r]], [[1pj1|1pj1]], [[1pfr|1pfr]], [[1piy|1piy]], [[6r1r|6r1r]], [[1pj0|1pj0]], [[1biq|1biq]], [[1rlr|1rlr]], [[1rsv|1rsv]], [[1piu|1piu]], [[1yfd|1yfd]], [[1piz|1piz]], [[1pm2|1pm2]], [[2alx|2alx]], [[1r65|1r65]], [[2x0z|2x0z]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0x OCA], [https://pdbe.org/2x0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x0x RCSB], [https://www.ebi.ac.uk/pdbsum/2x0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0x OCA], [https://pdbe.org/2x0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x0x RCSB], [https://www.ebi.ac.uk/pdbsum/2x0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. [[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.  
[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Stubbe J]]
[[Category: Stubbe, J]]
[[Category: Uhlin U]]
[[Category: Uhlin, U]]
[[Category: Yokoyama K]]
[[Category: Yokoyama, K]]
[[Category: Allosteric enzyme]]
[[Category: Alternative initiation]]
[[Category: Dna replication]]
[[Category: Nucleotide-binding]]
[[Category: Oxidoreductase]]
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