2xo5: Difference between revisions

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<StructureSection load='2xo5' size='340' side='right'caption='[[2xo5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2xo5' size='340' side='right'caption='[[2xo5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xo5]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XO5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xo5]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XO5 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TY2:3-AMINO-L-TYROSINE'>TY2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rsr|1rsr]], [[1mxr|1mxr]], [[3r1r|3r1r]], [[1jqc|1jqc]], [[1pim|1pim]], [[2r1r|2r1r]], [[4r1r|4r1r]], [[2xo4|2xo4]], [[2xav|2xav]], [[2xay|2xay]], [[2xap|2xap]], [[1piy|1piy]], [[2xak|2xak]], [[1biq|1biq]], [[1rlr|1rlr]], [[2xaw|2xaw]], [[1r65|1r65]], [[2alx|2alx]], [[1r1r|1r1r]], [[1av8|1av8]], [[1xik|1xik]], [[7r1r|7r1r]], [[1qfn|1qfn]], [[1mrr|1mrr]], [[2av8|2av8]], [[1rib|1rib]], [[1rnr|1rnr]], [[1jpr|1jpr]], [[5r1r|5r1r]], [[1pj1|1pj1]], [[1pfr|1pfr]], [[6r1r|6r1r]], [[1pj0|1pj0]], [[2xaz|2xaz]], [[2xax|2xax]], [[1rsv|1rsv]], [[1piu|1piu]], [[1yfd|1yfd]], [[2x0x|2x0x]], [[1piz|1piz]], [[1pm2|1pm2]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TY2:3-AMINO-L-TYROSINE'>TY2</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xo5 OCA], [https://pdbe.org/2xo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xo5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xo5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xo5 OCA], [https://pdbe.org/2xo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xo5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xo5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. [[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.  
[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Minnihan EC]]
[[Category: Minnihan, E C]]
[[Category: Seyedsayamdost MR]]
[[Category: Seyedsayamdost, M R]]
[[Category: Stubbe J]]
[[Category: Stubbe, J]]
[[Category: Uhlin U]]
[[Category: Uhlin, U]]
[[Category: Nucleotide binding]]
[[Category: Oxidoreductase]]
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