2xof: Difference between revisions

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<StructureSection load='2xof' size='340' side='right'caption='[[2xof]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2xof' size='340' side='right'caption='[[2xof]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XOF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XOF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NIY:META-NITRO-TYROSINE'>NIY</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=NIY:META-NITRO-TYROSINE'>NIY</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rsr|1rsr]], [[1mxr|1mxr]], [[3r1r|3r1r]], [[4r1r|4r1r]], [[1pim|1pim]], [[1jqc|1jqc]], [[2r1r|2r1r]], [[2xo4|2xo4]], [[2xav|2xav]], [[2xay|2xay]], [[2xap|2xap]], [[1piy|1piy]], [[2xak|2xak]], [[1biq|1biq]], [[2xaw|2xaw]], [[2xo5|2xo5]], [[2alx|2alx]], [[1r65|1r65]], [[1r1r|1r1r]], [[1av8|1av8]], [[7r1r|7r1r]], [[1xik|1xik]], [[1rnr|1rnr]], [[1rib|1rib]], [[1mrr|1mrr]], [[2av8|2av8]], [[1jpr|1jpr]], [[5r1r|5r1r]], [[1pj1|1pj1]], [[1pfr|1pfr]], [[6r1r|6r1r]], [[1pj0|1pj0]], [[2xaz|2xaz]], [[2xax|2xax]], [[1rsv|1rsv]], [[1piu|1piu]], [[1yfd|1yfd]], [[2x0x|2x0x]], [[1piz|1piz]], [[1pm2|1pm2]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xof OCA], [https://pdbe.org/2xof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xof RCSB], [https://www.ebi.ac.uk/pdbsum/2xof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xof ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xof OCA], [https://pdbe.org/2xof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xof RCSB], [https://www.ebi.ac.uk/pdbsum/2xof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xof ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.  
[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Stubbe J]]
[[Category: Stubbe, J]]
[[Category: Uhlin U]]
[[Category: Uhlin, U]]
[[Category: Yokoyama K]]
[[Category: Yokoyama, K]]
[[Category: Allosteric enzyme]]
[[Category: Dna replication]]
[[Category: Oxidoreductase]]
[[Category: Radical storage]]