3zm9: Difference between revisions
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<StructureSection load='3zm9' size='340' side='right'caption='[[3zm9]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3zm9' size='340' side='right'caption='[[3zm9]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zm9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3zm9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZM9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMQ:1-(4-(4-(4-((6-AMINO-9H-PURIN-9-YL)METHYL)PHENYL)BUTYL)BENZYL)-4-+(DIMETHYLAMINO)PYRIDINIUM'>QMQ</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMQ:1-(4-(4-(4-((6-AMINO-9H-PURIN-9-YL)METHYL)PHENYL)BUTYL)BENZYL)-4-+(DIMETHYLAMINO)PYRIDINIUM'>QMQ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm9 OCA], [https://pdbe.org/3zm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3zm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm9 OCA], [https://pdbe.org/3zm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3zm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Conejo-Garcia | [[Category: Conejo-Garcia A]] | ||
[[Category: Entrena | [[Category: Entrena A]] | ||
[[Category: Espinosa | [[Category: Espinosa A]] | ||
[[Category: Gervasio | [[Category: Gervasio FL]] | ||
[[Category: Hurtado-Guerrero | [[Category: Hurtado-Guerrero R]] | ||
[[Category: Rubio-Ruiz | [[Category: Rubio-Ruiz B]] | ||
[[Category: Sahun-Roncero | [[Category: Sahun-Roncero M]] | ||
[[Category: Saladino | [[Category: Saladino G]] | ||
[[Category: Velazquez-Campoy | [[Category: Velazquez-Campoy A]] | ||
Latest revision as of 11:06, 20 December 2023
The mechanism of allosteric coupling in choline kinase a1 revealed by a rationally designed inhibitor
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