4b0c: Difference between revisions

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<StructureSection load='4b0c' size='340' side='right'caption='[[4b0c]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4b0c' size='340' side='right'caption='[[4b0c]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b0c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B0C FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b0c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B0C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C9H:5-(PENTYLSULFANYL)-1H-1,2,4-TRIAZOLE'>C9H</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b0b|4b0b]], [[4b0i|4b0i]], [[4b8u|4b8u]], [[4fq9|4fq9]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C9H:5-(PENTYLSULFANYL)-1H-1,2,4-TRIAZOLE'>C9H</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-hydroxyacyl-[acyl-carrier-protein]_dehydratase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.59 4.2.1.59] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0c OCA], [https://pdbe.org/4b0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b0c RCSB], [https://www.ebi.ac.uk/pdbsum/4b0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b0c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0c OCA], [https://pdbe.org/4b0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b0c RCSB], [https://www.ebi.ac.uk/pdbsum/4b0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b0c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FABA_PSEAE FABA_PSEAE]] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).  
[https://www.uniprot.org/uniprot/FABA_PSEAE FABA_PSEAE] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Duthie, F G]]
[[Category: Pseudomonas aeruginosa]]
[[Category: McMahon, S A]]
[[Category: Duthie FG]]
[[Category: Moynie, L]]
[[Category: McMahon SA]]
[[Category: Naismith, J H]]
[[Category: Moynie L]]
[[Category: Bacterial virulence]]
[[Category: Naismith JH]]
[[Category: Drug discovery]]
[[Category: Fatty acid biosynthesis]]
[[Category: Lyase]]
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