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<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t|1e5t]], [[1e8m|1e8m]], [[1e8n|1e8n]], [[1h2w|1h2w]], [[1h2x|1h2x]], [[1h2y|1h2y]], [[1h2z|1h2z]], [[1o6f|1o6f]], [[1o6g|1o6g]], [[1qfm|1qfm]], [[1qfs|1qfs]], [[1uoo|1uoo]], [[1uop|1uop]], [[1uoq|1uoq]], [[1vz2|1vz2]], [[1vz3|1vz3]], [[2xdw|2xdw]], [[4amy|4amy]], [[4amz|4amz]], [[4an0|4an0]], [[4an1|4an1]], [[4ax4|4ax4]], [[4bcb|4bcb]], [[4bcc|4bcc]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [https://pdbe.org/4bcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [https://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [https://pdbe.org/4bcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [https://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.  
[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pig]]
[[Category: Sus scrofa]]
[[Category: Prolyl oligopeptidase]]
[[Category: Augustyns K]]
[[Category: Augustyns, K]]
[[Category: Baekelandt V]]
[[Category: Baekelandt, V]]
[[Category: Cheng JD]]
[[Category: Cheng, J D]]
[[Category: DeMeester I]]
[[Category: DeMeester, I]]
[[Category: Fulop V]]
[[Category: Fulop, V]]
[[Category: Gerard M]]
[[Category: Gerard, M]]
[[Category: Joossens J]]
[[Category: Joossens, J]]
[[Category: Lambeir AM]]
[[Category: Lambeir, A M]]
[[Category: Rea D]]
[[Category: Rea, D]]
[[Category: VanDerVeken P]]
[[Category: VanDerVeken, P]]
[[Category: VanElzen R]]
[[Category: VanElzen, R]]
[[Category: Alpha-beta-hydrolase]]
[[Category: Alzheimers disease]]
[[Category: Amnesia]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Parkinsons disease]]

Latest revision as of 11:47, 20 December 2023

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor

4bcd, resolution 1.50Å

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