4bdt: Difference between revisions

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<StructureSection load='4bdt' size='340' side='right'caption='[[4bdt]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='4bdt' size='340' side='right'caption='[[4bdt]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bdt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BDT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bdt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BDT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HUW:HUPRINE+W'>HUW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.104&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b41|1b41]], [[1f8u|1f8u]], [[1fsc|1fsc]], [[1fss|1fss]], [[1ku6|1ku6]], [[1mah|1mah]], [[1puv|1puv]], [[1puw|1puw]], [[1vzj|1vzj]], [[2clj|2clj]], [[2x8b|2x8b]], [[4bds|4bds]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=HUW:HUPRINE+W'>HUW</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bdt OCA], [https://pdbe.org/4bdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bdt RCSB], [https://www.ebi.ac.uk/pdbsum/4bdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bdt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bdt OCA], [https://pdbe.org/4bdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bdt RCSB], [https://www.ebi.ac.uk/pdbsum/4bdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bdt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> [[https://www.uniprot.org/uniprot/TXFA2_DENAN TXFA2_DENAN]] This three-finger toxin selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish acetylcholinesterase (AChE) at picomolar concentrations. It is highly specific for the peripheral site on acetylcholinesterase. It has been called fasciculin since after injection into mice it cause severe, generalized and long-lasting (5-7 hours) fasciculations. The whole venom has anticoagulant activity, and the various components seem to act synergistically.
[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetylcholinesterase]]
[[Category: Dendroaspis angusticeps]]
[[Category: Dendroaspis angusticeps]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carletti, E]]
[[Category: Carletti E]]
[[Category: Jean, L]]
[[Category: Jean L]]
[[Category: Nachon, F]]
[[Category: Nachon F]]
[[Category: Nicolet, Y]]
[[Category: Nicolet Y]]
[[Category: Renard, P Y]]
[[Category: Renard P-Y]]
[[Category: Ronco, C]]
[[Category: Ronco C]]
[[Category: Trovaslet, M]]
[[Category: Trovaslet M]]
[[Category: Alpha-beta hydrolase]]
[[Category: Butyrylcholinesterase]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Inhibition]]
[[Category: Nerve transmission]]
Retrieved from "https://proteopedia.org/4bdt"