1p7q: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1p7q.jpg|left|200px]] | [[Image:1p7q.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1p7q", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_1p7q| PDB=1p7q | SCENE= }} | |||
| | |||
| | |||
}} | |||
'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor''' | '''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor''' | ||
| Line 31: | Line 28: | ||
[[Category: Thomas, L M.]] | [[Category: Thomas, L M.]] | ||
[[Category: Willcox, B E.]] | [[Category: Willcox, B E.]] | ||
[[Category: | [[Category: Hla-a2/lir-1 complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:47:20 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 01:47, 3 May 2008
Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor
Overview
Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1P7Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:12897781 Page seeded by OCA on Sat May 3 04:47:20 2008
